PD-1/PD-L1 signal in tumor microenvironment can mediate the inhibition of T-cells.35, 36 PD-1 inhibitors have been demonstrated to directly induce Interferon γ (IFN-γ) production of activated T-cells, which induces IL-12 production by intra-tumor DC subpopulations. Here, CD274 is linked to neoplasm.