In addition, Tumor-Associated Macrophages (TAMs) have plasticity and can differentiate into the inflammatory M1 type or the M2 type.51, 52, 53 PD-1+ TAMs have similar surface molecular expression patterns and functions to M2-type macrophages, such as persistently enhanced expression of CD206 and IL-10, reduced expression of HLA-DR, CD64 and IL-12, and significantly enhanced ability to suppress CD8 + T-cells.54 The gene discussed is CD8A; the disease is neoplasm.