SREBP2 as well as NF-kB, both transcription factors activated upon SARS-CoV-2 infection, can elevate PCSK9 expression (Grewal & Buechler, 2022; Elahi et al, 2023; Essalmani et al, 2023) and NF-kB or SREBP2 inhibitors normalized PCSK9 levels in PBMCs of COVID-19–infected patients (Lee et al, 2020). The gene discussed is NFKB1; the disease is COVID-19.