Analysis for risk of infection among IMID cohorts by immunosuppressive drug class exposure showed a significantly increased risk of infection among users of anti-TNF (HR: 1.8, 95% CI 1.6 to 2.0), systemic corticosteroid (HR: 1.2, 95% CI 1.0 to 1.5), and rituximab and other immunosuppressant (HR: 1.3, 95% CI 1.1 to 1.4; figure 3). Here, TNF is linked to infection.