CD4 and AIDS: The most prevalent oral symptom of the human immunodeficiency virus/ acquired immunodeficiency syndrome (HIV/AIDS) with low count of cluster differentiation 4 (CD4) in adults or children is oral candidiasis (OC), which can affect the tongue and other oral mucosal locations.1, 2As the viral disease progresses, it has been observed that nearly all HIV-infected individuals have aCandidacolonization and that up to 90 to 95% of them acquire clinical lesions.