PC ProspecJve Cohort; RCT- Randomized Clinical Trial; CSS - Cross-secJonal study; SD Standard DeviaJon; Confidence Interval IC; LDL - Low-Density Lipoprotein; DM - Diabetes mellitus; SHA - Systemic Arterial Hypertension; CS - Can’t Say; NA - Not Applicable; FSH - Follicle SJmulaJng Hormone; LH - Luteinizing Hormone; SHBG - sex hormone binding globulin; DHEA - Dehydroepiandrosterone; CV - Cardiovascular; CVD - Cardiovascular Disease;. This evidence concerns the gene PLOD1 and diabetes mellitus.