Of note, we observed a bidirectional relationship between CRP and MetS (β1 = 0.028; 95% CI = 0.018–0.038 and β2 = 0.046; 95% CI = 0.037, 0.055), but the impact of inflammation on metabolic disorders was more pronounced (P < 0.001) (Figure 2, Panel B; Figure S1 in the Online Supplementary Document). This evidence concerns the gene CRP and metabolic disease.