Furthermore, the heritability of hepatic fat accumulation and NAFLD has also been reported, where mutations in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene and the transmembrane 6 superfamily 2 (TM6SF2) gene appear to play an important role [9–12]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.