Notably, ASPSCR1-TFE3 is also implicated in the pathogenesis of alveolar soft part sarcoma (ASPS), a rare soft tissue sarcoma (11, 12), which, like tRCC, may present in children and young adults (13). The gene discussed is ASPSCR1; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.