However, tRCC differed from the dysmorphic kidneys by the induction of pathways related to cell proliferation (E2F, Myc, cell cycle, DNA replication, mitotic spindle, etc.)(Figure 5B and Supplemental Figure 8B). Here, MYC is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.