TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Principal component analysis (PCA) revealed that the dysmorphic ASPSCR1-TFE3 fetal kidneys clustered in proximity to age-matched controls and away from tRCC tumors (and adult kidney controls), likely indicating dominance of developmental stage over other ASPSCR1-TFE3–related programs (Figure 5A).