tRCC is characterized by chromosomal translocations involving 3 genes of the MiT family of transcription factors: TFE3 (Xp11.23), TFEB (6p21.1), and MITF (3p13) (4–7). The gene discussed is MITF; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.