Notably, ASPSCR1-TFE3 is also implicated in the pathogenesis of alveolar soft part sarcoma (ASPS), a rare soft tissue sarcoma (11, 12), which, like tRCC, may present in children and young adults (13). This evidence concerns the gene TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.