Seeking to understand the relationship between tRCC and the dysmorphic process in Pax8-Cre; ASPSCR1-TFE3LSL/+ fetuses, we also evaluated kidneys from 5 fetuses (as well as from 3 Pax8-Cre controls; Supplemental Tables 5 and 9). The gene discussed is PAX8; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.