Specifically, mTOR, epithelial-mesenchymal transition (EMT), and inflammation (inflammatory response, IL-6/JAK/STAT3, TLR, TNF-α/NF-κB, allograft rejection) characterized both dysmorphic kidneys and tRCC. Here, NFKB1 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.