There were substantial similarities between retro-orbital/brain tumors and tRCC, including EMT, lysosome, inflammation (inflammatory response, TNF-α/NF-κB, allograft rejection), and cell proliferation (E2F, Myc, cell cycle, DNA replication, mitotic spindle) (Figure 5B and Supplemental Figure 8B). This evidence concerns the gene MYC and brain neoplasm.