To evaluate the importance of mTORC1 activation in tRCC tumor development, we treated Sglt2-Cre; ASPSCR1-TFE3LSL/+ mice with rapamycin using a dosing regimen we previously showed mimicked human exposures (27). The gene discussed is ASPSCR1; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.