There were substantial similarities between retro-orbital/brain tumors and tRCC, including EMT, lysosome, inflammation (inflammatory response, TNF-α/NF-κB, allograft rejection), and cell proliferation (E2F, Myc, cell cycle, DNA replication, mitotic spindle) (Figure 5B and Supplemental Figure 8B). Here, TNF is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.