These include the inflammatory and neuroinflammatory response, mTORC1 signaling, IFN-γ response (Th1 pathway) and TNF-α signaling for both HD and uRRMS, and IL-6-STAT3 signaling (IL-17 pathway) exclusively for uRRMS (Figure 4C, Supplemental Figure 5, and Supplemental Tables 1 and 2). The gene discussed is TNF; the disease is Huntington disease.