PLG and ischemic stroke: Indeed, plasminogen/plasmin system and its modulators tPA and PAI‐1 have been shown to not only have critical roles in modulating astrocytes, neurons, microglia and pericytes but also to have profound effects in several CNS conditions, including ischaemic stroke,2 severe traumatic brain injury8 and also in neurodegenerative disorders such as Parkinson's9 and Alzheimer's10 diseases.