INS and type 2 diabetes mellitus: Therefore, this study evaluates the interactions of weight loss and PA volumes in association with the risk of cardiovascular events by conducting a post hoc secondary analysis of the Look AHEAD trial among individuals with T2D and overweight or obesity, defined as a body mass index (calculated as weight in kilograms divided by height in meters squared) of 25 or greater (or ≥27 if currently taking insulin).