Multiple studies have demonstrated that administration of the recombinant p75 soluble TNFR (sTNFR) peptide (etanercept) intrathecally depleted mechanical allodynia in a mouse model of neuropathic pain, while counteracting antibodies aimed against the p55 TNF receptor (TNFR) reduced hyperalgesia related to the heat and mechanical allodynia [48–50]. Here, TNFRSF1A is linked to Pain.