In this study, we demonstrated that the most common pathogenic/likely pathogenic gene alterations in a small mixed RCC cohort were found in CHEK2, VHL, PBRM1, SETD2, and BRCA2. In addition, we discovered an association between longer TFFS in patients with SETD2 gene alterations and shorter TFFS in patients with BRCA2 mutations. Here, SETD2 is linked to renal cell carcinoma.