STAT3 and neoplasm: We found that MBM with high immune score were enriched in genes associated with MET and STAT3 signaling, tumor inflammation, stress and senescence (SenMayo [58]) (Fig. 3a) and featured the presence of reactive microglia, astrocytes and immune cell subsets, among them stem cell-like CD8+ T cells (TCF7) [46] in tumors, absent in BMCs.