APBB1IP and melanoma: APBB1IP has been identified as a conserved microglial gene [20] and binding partner of amyloid precursor protein (APP), Tau, 14–3-3 g, and glycogen synthase kinase 3 b (GSK3 b) was associated with actin dynamics and retinoic acid signaling [31, 35] and was significantly (MBM: R = 0.86, p < 2.2e-16) correlated with immune score (Fig. 1k) and survival of melanoma patients (Supplementary Fig. 1d-e).