Specifically relevant to the CRC microenvironment and senescence are the subsets of CAF subsets described by Pelka et al. (2021) that exhibited elevated levels of an inflammatory program, including genes MMP1, MMP3, CXCL8 and CXCL1, which are colon fibroblast SASP components observed in our study. This evidence concerns the gene MMP1 and colorectal carcinoma.