Further mechanistic exploration indicated that DOCK7 packaged in TAM‐EVs could activate RAC1 in CRC cells, and subsequently upregulate ABCA1 expression by phosphorylating AKT and FOXO1, ultimately regulating cholesterol metabolism and increasing membrane fluidity to regulate the motility and invasiveness of CRC cells (Figure 8). The gene discussed is ABCA1; the disease is colorectal carcinoma.