To examine whether the increased pulmonary DCs and their activity contribute to the increased T cell activation and tumoricidal ability for lung cancer suppression in NF-κB2–KO mice, we compared in vitro the abilities of NF-κB2–KO and WT DCs in activating naive NF-κB2–KO or WT T cells. This evidence concerns the gene NFKB2 and lung carcinoma.