Notably, pharmacological inhibition of STING activation with a small molecule inhibitor of STING palmitoylation reduces adverse cardiac remodeling and dysfunction in a mouse model of chronic kidney disease [74] and nitro fatty acid treatment improves cardiac function and reduces myocardial fibrosis in a genetic mouse model of dilated cardiomyopathy [42]. This evidence concerns the gene STING1 and Myocardial fibrosis.