Cardiomyocyte-specific transgenic mice overexpressing zDHHC3 recapitulate this phenotype, exhibiting severe dilated cardiomyopathy and bradycardia followed by lethality around 6 weeks of age when zDHHC3 is overexpressed from around birth in ventricular cardiomyocytes (α-myosin heavy chain (MHC) promoter-driven expression) [24]. The gene discussed is ZDHHC3; the disease is dilated cardiomyopathy.