Further investigation is needed to determine the role of palmitoylated Rac1 in cardiomyocytes, including if there are differential effectors and functions of palmitoylated Rac1 versus depalmitoylated Rac1 (which can still associate with membranes via its C-terminal polybasic domain and geranylgeranyl lipidation) and if Rac1-dependent Nox2 activity, cardiac hypertrophy and oxidative stress [60] require its palmitoylation. The gene discussed is RAC1; the disease is cardiac hypertrophy.