ZDHHC3 and dilated cardiomyopathy: An in vivo gain-of-function screen with adeno-associated virus 9 (AAV9)-mediated overexpression of select zDHHC enzymes in the heart found no overt cardiac phenotype from overexpression of the sarcolemmal enzyme zDHHC5, Golgi-localized zDHHC13, or the ER enzyme zDHHC6, whereas overexpression of the closely related Golgi enzymes zDHHC3 or zDHHC7 caused severe lethal dilated cardiomyopathy [24].