SELP and Venous thrombosis: Interestingly, lack of antioxidative protein paraoxonase-2 in mice leads to enhanced oxidative stress, TF activity, and platelet activation.49 We therefore propose that preventing activation of monocytes and neutrophils by inhibiting P-selectin-dependent processes is beneficial in venous thrombosis due to reduced infiltration and activation of these innate immune cells at the site of thrombus formation preventing early stabilization of the thrombus and facilitating thrombus resolution.