Given that the aforementioned bacteria have the capacity to convert tryptophan, we reasoned that supplementation of CBM588 may subsequently modulate the impact of tryptophan metabolism on the conversion of Tregs into TH17-like T cells.25 Accordingly, the frequency of Ruminococcaceae and the paucity of Rorγ+Tregs within the tumor-draining lymph nodes were both inversely correlated to the colonic transcript level of indoleamine 2,3-Dioxygenase 1 [IDO-1] (Figure 5b–c). Here, IDO1 is linked to neoplasm.