RORC and neoplasm: This accords with previous report describing a capacity of CBM588 to alleviate the severity of intestinal damage by promoting IL-10 by intestinal phagocytes in different preclinical models.13,34,35 Under this specific circumstance, the greater ability of LPMCs to secrete IL-10 in response to CBM588 support the idea that such tolerogenic effect was associated with a lowered expansion of Rorγ+Tregs at the tumor-draining lymph nodes.