Other potentially interesting targets for MS antibodies that have been proposed in recent years are chloride-channel protein Anoctamin 2 (ANO2) (Tengvall et al., 2019), which is a transmembrane protein for modulation for neural-excitability; alpha-crystallin B (CRYAB), which is expressed by oligodendrocytes and may have a protective effect by down-regulating the innate immune system (Thomas et al., 2023). Here, CRYAB is linked to myeloid sarcoma.