The results indicated that GC cells exhibited enhanced migration and invasion in the co-culture system with EGR1 up-regulated HMrSV5, while the migration and invasion of GC cells decreased when co-cultured with EGR1 down-regulated HMrSV5 (Fig. 2A-B; Supplementary Fig. 2A-B). The gene discussed is EGR1; the disease is gastric cancer.