Further research had also shown that in bladder cancer cells, METTL16 could specifically recognize the m6A sites of the 3'-UTR in PMEPA1 mRNA, which decreased the stability of PMEPA1 mRNA and eventually led to a decrease in the protein level of PMEPA1 in an m6A-dependent manner. The gene discussed is METTL16; the disease is urinary bladder cancer.