Moreover, DADS treatment abrogated the POU2F1 over-expression-decreased NADP+/NADPH ratios in HCT116 CRC cells while the same treatment synergistically further elevated the POU2F1 silencing-increased NADP+/NADPH ratios in SW620 CRC cells (P<0.05 for all, Figure 4G). Here, POU2F1 is linked to colorectal carcinoma.