Actually, DADS treatment significantly down-regulated the expression of nucleotide synthesis-related enzymes, such as ADSL (adenylosuccinate lyase), ATIC (formyltransferase/IMP cyclohydrolase), GMPS (Guanine Monophosphate Synthase) in CRC cells, compared to the vehicle DMSO group (Figure S3C), suggesting that DADS might suppress nucleotide synthesis and the DNA damage repair. Here, ADSL is linked to colorectal carcinoma.