POU2F1 and colorectal carcinoma: To further elucidate how DADS treatment reduced the POU2F1 protein stability, CRC cells were treated with vehicle or DADS alone or together with MG132 (a proteasome inhibitor) or 3-MA (an inhibitor of lysosome-autophagy pathway) and their POU2F1 protein levels were analyzed by Western blot assays.