As shown in Fig. 4B-E, overexpression of GALNT12 in GALNT12 low-expressed human PCa cells (DU145 and PC-3) (Fig. S3A) significantly reduced the migration and invasion abilities of PCa cells and suppressed the proliferation ability of PCa cells (Fig. S3D-G), while mutation in catalytic structural domain of GALNT12 could completely remove its suppression effects on migration and invasion abilities of PCa cells (Fig. 4F-I). Here, GALNT12 is linked to posterior cortical atrophy.