To evaluate whether GALNT12 exerted its effects on bone metastasis of PCa through the glycosylase function, we constructed a human GALNT12 overexpression plasmid (hGALNT12-WT) (Fig. S3B and Fig. 4A) and a corresponding plasmid with mutation in the catalytic structural domain of GALNT12 (hGALNT12-MUT) (Fig. S3C and Fig. 5H). The gene discussed is GALNT12; the disease is posterior cortical atrophy.