ACTA1 and Hepatic fibrosis: In HSCs, experimental downregulation of augmenter of liver regeneration (ALR) can naturally occur in the process of liver fibrosis, and promote the expressions of Col I, α-SMA, and ras-related C3 botulinum toxin substrate 1 (rac1), which is correlated with microRNA-181a induced by TGF-β124.