SMAD4 and hepatocellular carcinoma: As shown in Figure 5A, ubiquitin-specific protease 10 (USP10), which is abnormally activated in a variety of malignant tumor, can bind specifically to SMAD4 and stabilize the effect of SMAD4 by increasing its deubiquitination, and further lead to the metastasis of human hepatoma cells Bel-740286.