As shown in Figure 5A, ubiquitin-specific protease 10 (USP10), which is abnormally activated in a variety of malignant tumor, can bind specifically to SMAD4 and stabilize the effect of SMAD4 by increasing its deubiquitination, and further lead to the metastasis of human hepatoma cells Bel-740286. The gene discussed is USP10; the disease is cancer.