The translation of TGF-β2 was upregulated by METTL1-dependent tRNA m7G modification, which could induce the differentiation of peripheral blood mononuclear cells (PBMCs) into PMN-MDSCs and increase their infiltration, thereby suppress the function of CD8+ T cells and promote HCC progression 76,113. The gene discussed is METTL1; the disease is hepatocellular carcinoma.