For example, in NPC, m7G modification of tRNAs catalyzed by METTL1/WDR4 complex could accelerate codon recognition and mRNA translation, which contributed to activation of WNT/β-catenin pathway and subsequently promoted chemoresistance of NPC cells to cisplatin and docetaxel 73. This evidence concerns the gene WDR4 and nasopharyngeal carcinoma.