Recent research suggests that flavonoids are implicated in the regulation of key pathways, including the NF-κB, JAK/STAT, TLR, and CREB pathways, which are implicated in regulating neuroinflammation, which further induces the pathogenesis and progression of psychiatric and neurological disorders, including ASD 146,147. The gene discussed is NFKB1; the disease is nervous system disorder.