The search used the keywords listed below: "Polyphenols, NF-κB pathway, neurological disorders, and neuroinflammation." Furthermore, the secondary keywords used were "Alzheimer's disease, Parkinson's disease, and Spinal cord injury." This review explores the potential of polyphenols in treating various diseases by modulating NF-κB pathways and their impact on NDs. This evidence concerns the gene NFKB1 and nervous system disorder.