The search used the keywords listed below: "Polyphenols, NF-κB pathway, neurological disorders, and neuroinflammation." Furthermore, the secondary keywords used were "Alzheimer's disease, Parkinson's disease, and Spinal cord injury." This review explores the potential of polyphenols in treating various diseases by modulating NF-κB pathways and their impact on NDs. Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.