A negative correlation was detected between PSME2 and the expression of a range of MMR genes in cancers including BLCA, BRCA, KICH, KIRC, KIRP, LIHC, OV, PRAD, SARC, SKCM, TGCT, THYM, and UCEC, with a particularly pronounced relationship in THCA (Figure 4A). The gene discussed is MRC1; the disease is cancer.