A pan-cancer analysis of associations between PSME2 and immune-related genes was also conducted (Figure S10), and TISMO was used to compare the expression of PSME2 between cancer cell lines treated in vitro with cytokines (Figure S11A) and in samples before and after in vivo anti-PD-1 and anti-CTLA4 treatment (Figure S11B). Here, CTLA4 is linked to cancer.