In addition, the regulation of TEM8 protein bythe E3 ubiquitin ligase ASB10 in triple-negative breast cancer tissues resulted in higher levels of TEM8 protein than in other subtypes of breast cancer, while the transcript levels were lower than in luminal breast cancer, suggesting that post-translational modification is also responsible for this discrepancy between the protein and mRNA expression levels 59. The gene discussed is ASB10; the disease is breast carcinoma.