IL1B and periodontitis: Interleukin (IL)-1β, predominantly secreted by macrophages, not only recruits immune cells to amplify the inflammatory response 4 but also triggers the degradation of collagen by increasing matrix metalloproteinases secretion 5 and promotes nuclear factor kappa B (NF-κB) ligand (RANKL) mediated osteoclastogenesis 6, eventually resulting in bone resorption in periodontitis.