BMP7 mutations have also been associated with syndromic and non-syndromic OFC, and a deletion at 20p12.3 that encompasses BMP2 has been linked to syndromic OFC (Wyatt et al., 2010; Sahoo et al., 2011; Williams et al., 2012; Yu et al., 2015). Here, BMP7 is linked to otofaciocervical syndrome 1.