BMPER and craniosynostosis: With respect to BMP signaling, a recent zebrafish study identified that GWAS variants associated with BMP2 lie in putative enhancer regions for BMP2 and BMPER, and that these enhancers likely drive the expression of these genes in the osteogenic fronts of the frontal bones, further implicating BMP signaling in suture homeostasis and craniosynostosis (Justice et al., 2012; He et al., 2023).