We also found that most immune cells, including activated B cells, activated CD4 T cells, activated CD8 T cells, activated dendritic cells, central memory CD4 T cells, effector memory CD8 T cells, gamma delta T cells, MDSCs, monocytes, natural killer T cells, regulatory T cells, and type 1 T helper cells, were more highly enriched in RA tissue, while eosinophils and memory B cells were less infiltrated in RA tissues (Figure 4(b)). Here, CD8A is linked to rheumatoid arthritis.