The importance of mGluR5 for modulating motor behavior has been reported in pharmacological (Mcgeehan et al., 2004; Guimaraes et al., 2015) as well as knockout (Gray et al., 2009; Jew et al., 2013; Ribeiro et al., 2014) studies in rodents, with solid agreement that mGluR5 blockade produces hyperkinesia. The gene discussed is GRM5; the disease is Hyperkinetic movements.