Lastly, a higher CD4+/CD8+ memory T-cell ratio was associated with a higher ARMSS score in blood and CSF but not in OCR-treated individuals, further supporting the putative benefit of preventing the accumulation of CD20dim CD4+ memory T cells into the CSF through life even of people with the progressive form of multiple sclerosis by treatments such as OCR. This evidence concerns the gene CD8A and multiple sclerosis.