The GSEA analysis demonstrated their association with various signaling pathways, including TGF-β signaling pathway, insulin signaling pathway, vascular endothelial growth factor signaling pathway, ErbB signaling pathway, B cell receptor signaling pathway, T cell receptor signaling pathway, oxidative phosphorylation, RNA degradation, apoptosis, NK cell-mediated cytotoxicity, prostate cancer, glioma, non-small cell lung cancer, and protein export-related pathways. Here, INS is linked to central nervous system cancer.