MUC16 and female reproductive organ cancer: This led to the identification of genes and pathways that were specific for each cluster: MUC16 (CA125), specifically expressed in Gynecological cancers, and “TERMINAL_FUCOSYLATION,” specific for Gastro-Intestinal cancers, which includes enzymes involved in the synthesis of Lewis antigens, as sialyl-Lewisa (sLea, CA19-9).