HLA-C and immune system disorder: Notably, genes like HLA-DRB1 and HLA-DRB5, situated in or near the human major histocompatibility complex (MHC) on chromosome 6 (Caillier et al., 2008), exhibit associations with immune diseases (Jacobson et al., 2008) (e.g., autoimmune thyroid disease) and cardiovascular traits (Klein and Danzi, 2016) (e.g., coronary artery disease).