Notably, genes like HLA-DRB1 and HLA-DRB5, situated in or near the human major histocompatibility complex (MHC) on chromosome 6 (Caillier et al., 2008), exhibit associations with immune diseases (Jacobson et al., 2008) (e.g., autoimmune thyroid disease) and cardiovascular traits (Klein and Danzi, 2016) (e.g., coronary artery disease). This evidence concerns the gene HLA-DRB5 and immune system disorder.