Insulin resistance is associated with reduced inhibition of hormone-sensitive lipase in adipose tissue, thereby augmenting portal flux of free fatty acid (FFA). FFA and triglycerides derived from FFA or FFA inhibit apolipoprotein B (apoB) degradation in the liver, thereby stimulating the overproduction of VLDL1 and is metabolically associated with a preponderance of small dense LDL and reduced large cholesterol-rich HDL2 [12]. The gene discussed is APOB; the disease is Insulin resistance.