Interleukin-6 (IL-6)/STAT3 could elevate miR-135b-5p level and that STAT3 directly bound the promoter of hsa-miR-135b-5p, a new positive feedback loop of the IL-6/STAT3/miR-135b/NF-κB was found in NSCLC and hsa-miR-135b-5p could be a potential therapeutic target for NSCLC [86]. This evidence concerns the gene IL6 and non-small cell lung carcinoma.