HSPA8 and neurodegenerative disease: Abnormal HSC70 or LAMP2A (lysosomal-associated membrane protein 2A) expression and CMA activity have been implicated in the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis and Parkinson’s disease (Coyne et al., 2017; Sirtori et al., 2020) It is possible that CMA might be also impaired in the nervous systems of F344-kk/kk rats.