Mutations in PLA2G6 have also been reported to be associated with a continuous clinical spectrum ranging from NAD to hereditary spastic paraplegia (HSP), a group of motor neurodegenerative disorders mainly characterized by slowly progressive spasticity and weakness of the lower limbs (Fink, 2013; Ozes et al., 2017; Elsayed et al., 2021; Murala et al., 2021). The gene discussed is PLA2G6; the disease is hereditary spastic paraplegia.