In their study, Zhuang et al., 2012 show TIM-3 positively stained on 92.9% of TILs and most infiltrated tumor-associated macrophages (TAMs) in lung cancer tissues, and 87% of NSCLC primary tumors were positive for TIM-3 (120). The gene discussed is HAVCR2; the disease is non-small cell lung carcinoma.