The tumor cells escape due to either a) the loss of TAA or TSA expression or by deviations in antigen processing or presentation by tumor cells, b) the loss of sensitivity of tumor cells to immune-induced cell-elimination mechanisms, including overexpression of antiapoptotic proteins BCL2 and STAT3, or c) immunosuppressive action of TME (56). The gene discussed is STAT3; the disease is neoplasm.