Tumor suppressor genes (TSG), that are regularly inactivated in NSCLC, are tumor protein p53 (TP53), cyclin-dependent kinase inhibitor 2A (CDKN2A), fragile histidine triad protein (FHIT), Ras association domain family protein1 isoform A (RASSF1A), Phosphatase and Tensin Homolog (PTEN), retinoblastoma 1 (RB1), and serine-threonine kinase 11 (STK11) (25). The gene discussed is FHIT; the disease is non-small cell lung carcinoma.