Impairs NK cell activity in destroying EBV-infected B cells and possessing various immunomodulatory activities by inhibiting cytokine expression. Also, it triggers less STAT3 phosphorylation, reduces anti-inflammatory gene expression, and inhibits M2 polarization in monocytes, contributing to autoimmune reactions in diseases like systemic lupus erythematosus (SLE). The gene discussed is STAT3; the disease is systemic lupus erythematosus.