Considered together with the data in Figures 3A–C, these results establish that FA-TLR7-1A will only induce inflammatory cytokine production in cells that express functional FRβ, and because FRβ is only activated in tumor (or inflamed) tissues, these data argue that FA-TLR7-1A should constitute a safe method for reprogramming TAMs and MDSCs in a tumor mass without inducing their toxic cytokine release in healthy tissues. This evidence concerns the gene FOLR2 and neoplasm.