Because a similar colocalization was also found by scRNA-seq in human ovarian, lung and breast cancer specimens (Figures 2E–G), we conclude that FRβ is commonly co-expressed in M2-like macrophages with TLR7 receptors (Supplementary Figures 6A–C) (4, 6, 7, 38). This evidence concerns the gene FOLR2 and breast cancer.