IL18 and neoplasm: Tumor-infiltrating B lymphocytes in PDAC differentiate into Regulatory B cells (Bregs) that produce IL-10 or IL-35 with the help of other immune cells such as Tregs and MDSCs, cytokines IL-18, CAFs, tumor-associated antigens, damage-associated molecular patterns, hypoxia, pancreatic microbiota, and metabolites in the TME (165, 166).