MICA and cancer: For instance, the DDR evident in GBM and several other cancers can induce expression of tumor-associated stress receptors including NKG2D ligands (NKG2DL) such as MHC-class-I-polypeptide-related sequence A (MICA) and UL-16 binding proteins (ULBP) 1-8 thereby sensitizing malignant cells to killing by the immune system’s NKG2D receptor-expressing first responders, such as NK cells, NKT cells, γδ T cells and some CD8+ αβ T cells.