Further investigation of the shared molecular pathways involved in the pathophysiology of MASP-1-induced trauma and sepsis revealed that IL6/JAK/STAT3 signaling, TLR pathway, NF-κB signaling pathway, checkpoint, HLA, T-cell co-inhibition, T-cell co-stimulation, and necrosis were shared between trauma and sepsis samples. This evidence concerns the gene STAT3 and Sepsis.