The results of the Mantel test revealed that MASP-1 expression was significantly negatively associated with the proportion of CD8 T cells (p < 0.05) and IL6/JAK/STAT3 signaling scores (p < 0.05), while IL6/JAK/STAT3 signaling score was significantly negatively correlated with the proportion of CD8 T cells (p < 0.05) in sepsis (Figure 9C) and trauma (Figure 9D). Here, IL6 is linked to Sepsis.