In the present study, we comprehensively analyzed the role of MASP-1 in trauma and sepsis using five sepsis (GSE54514, GSE57065, GSE95233, GSE131761, and GSE154918), two trauma (GSE11375 and GSE64711), and one sepsis and trauma (GSE69063) GEO datasets. This evidence concerns the gene MASP1 and Sepsis.