The RNA and protein levels of METTL3 and FTO in RWPE-1, LNCaP, PC-3, 22RV1, and DU145 cells were assessed, and the results showed that METTL3 expression was up-regulated while FTO expression was down-regulated in prostate cancer cells (Fig. 1J and K). This evidence concerns the gene FTO and Familial prostate cancer.