AGT and diabetic cardiomyopathy: In vivo experiments revealed that dapagliflozin reduced interleukin (IL)-1β expression and can downregulate the activity of [Na+] and [Ca2+]-related ion channels to alleviate mitochondrial reactive oxygen species, thereby improving angiotensin II (Ang II)-induced diabetic cardiomyopathy in db/db mice (Table 3) (Arow et al., 2020).