AKT1 and cancer: The docking results showed that AIL had the strongest binding affinity with PI3K and AKT (AIL had the lowest binding energy with PI3K and AKT of −8.6 kcal/mol and −7.5 kcal/mol, respectively) (Ren et al., 2023), indicating that PI3K and AKT are key targets for the anti-cancer activity of AIL.