Notably, the PI3K/AKT pathway differs from the regulatory mechanism of AIL in other tumors mentioned above, such as non-small cell lung cancer (Ni et al., 2017), acute myeloid leukemia (Wei et al., 2018), bladder cancer (Daga et al., 2019), breast cancer (Wang et al., 2018), gastric cancer (Chen et al., 2017), etc. Here, AKT1 is linked to urinary bladder cancer.