Nikkhah et al. (2023) showed through a meta-analysis of the results of seven human studies and five animal studies that the genera that decreased in individuals with age-related sarcopenia were Lachnospiraceae, Fusicatenibacter, Roseburia, Eubacterium, Lachnoclostridium, and Slackia. Observational studies have shown that Lachnospiraceae and Aminopeptidase O Protein co-regulate angiotensin and muscle metabolism (Bai et al., 2021; Bajaj et al., 2021; Schulz et al., 2021; Sun et al., 2021). The gene discussed is AOPEP; the disease is sarcopenia.